Floer theory is a power tool in the study of low dimensional topology, leading to many milestone results in the field. There are four major branches of Floer homologies, all of which have distinct features and applications. Among them, Heegaard Floer homology, monopole Floer homology, and embedded contact homology are known to be isomorphic, yet their relationship with Instanton Floer homology remains enigmatic. This talk will explore the connection between Instanton and Heegaard Floer homology. I will first present a result joint with Baldwin and Ye that illuminates some of the interplay between these two theories. Time permitted, I will delve into ongoing research that further investigates these intriguing connections.